and Paediatric
Plaque Psoriasis
Arthritis
UNIQUE mode of action of ustekinumab:
IL12/IL23-receptor binding inhibition
Ustekinumab is a fully human IgG1κ monoclonal antibody that binds with specificity to the shared p40 protein subunit of pro-inflammatory cytokines IL-12 and IL-23 to prevent them from binding to their receptors, expressed on the surface of immune cells, therefore inhibiting inflammatory processes early1
UZPRUVO® IN DERMATOLOGY & RHEUMATOLOGY
POSOLOGY OPTIONS1
Choose between two dose strengths to suit individual treatment needs
Maintenance:
SC Injection*
Presentation:
Pre-filled Syringe
SC, subcutaneous
Dosing1
BW, body weight; PFS, pre-filled syringe; Q12W, every 12 weeks; SC, subcutaneous
1. Uzpruvo® SmPC (Feb. 2024).
Comparatively Fewer Treatments:
Dermatology & Rheumatology Treatment Regimes1-3
Example of total doses in the first year of treatment (52 weeks) for adult patients with Crohn's disease
Q2W, every 2 weeks; Q4W, every 4 weeks; Q12W, every 12 weeks; SC, subcutaneous; W, week(s)
*Uzpruvo® weight-based dosage regime: BW ≤100 kg: 45 mg, BW 100 kg: 90 mg;
**Numbers based on the use of a 300 mg dosage. Secukinumab weight-based dosage frequency is Q4W for patient with BW 90 kg and Q2W with BW ≥90 kg2
1. Uzpruvo® SmPC (Feb. 2024); 2. Cosentyx® SmPC (Aug. 2023); 3. Taltz® SmPC (Feb. 2023).
Adapted from Feldman SR et al. 20231
BL, baseline; BSA, body surface area; DLQI, Dermatology life quality index; EoS, end of study; PASI, Psoriasis Area and Severity Index; Q12W, every 12 weeks; SC, subcutaneous; sPGA, statistic physician's global assessment
*Stelara®; **≤100 kg body weight: 45 mg, >100 kg body weight: 90 mg
1. Feldman SR et al. Expert Opin Biol Ther. 2023;23(3):253-60. DOI: 10.1080/14712598.2023.2235263.
Adapted from Feldman SR et al. 20231
AE, adverse event; RP, reference product; TEAE, treatment-emergent adverse event
*Stelara® 1. Feldman SR et al. Expert Opin Biol Ther. 2023;23(3):253-60. DOI: 10.1080/14712598.2023.2235263.